{"id":529,"date":"2021-05-23T11:00:00","date_gmt":"2021-05-23T10:00:00","guid":{"rendered":"http:\/\/biopedia.co.uk\/?p=529"},"modified":"2021-07-22T14:34:46","modified_gmt":"2021-07-22T13:34:46","slug":"33-lethal-alleles","status":"publish","type":"post","link":"http:\/\/biopedia.co.uk\/?p=529","title":{"rendered":"33- Lethal Alleles"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-rich is-provider-spotify wp-block-embed-spotify wp-embed-aspect-21-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Spotify Embed: 33- Lethal Alleles\" width=\"100%\" height=\"232\" allowtransparency=\"true\" frameborder=\"0\" allow=\"encrypted-media\" src=\"https:\/\/open.spotify.com\/embed\/episode\/1dr3cAXeH0BjS29xahthFX\"><\/iframe>\n<\/div><\/figure>\n\n\n<p>At A Level, we are taught that dominant: recessive traits are in a 3:1 ratio for any trait in which only one gene encodes for it. However, it&#8217;s not always that simple. Enter lethal alleles&#8230;<\/p>\n<p>Sources for this episode: 1) Author unknown, Wikipedia (date unknown), Lethal allele (online) [Accessed 26\/03\/2021]. 2) Author unknown, Wikipedia (date unknown), Manx cat (online) [Accessed 27\/03\/2021]. 3) Gao, Z., Waggoner, D., Stephens, M., Ober, C. and Przeworski, M. (2015), An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans. Genetics 199: 1243- 1254. 4) Roos, R. A. C. (2010), Huntingdon&#8217;s disease: a clinical review. Orphanet Journal of Rare Diseases 2010 5:40. 5) For an example of the deleterious effects of inbreeding as discussed in today&#8217;s episode, see the Wikipedia or Encyclopaedia Britannica pages on Charles II of Spain. I might come back to him and his ailments in a separate episode, but until then he will also serve as a good example.<\/p>","protected":false},"excerpt":{"rendered":"<p>At A Level, we are taught that dominant: recessive traits are in a 3:1 ratio for any trait in which only one gene encodes for it. However, it&#8217;s not always that simple. Enter lethal alleles&#8230; Sources for this episode: 1) Author unknown, Wikipedia (date unknown), Lethal allele (online) [Accessed 26\/03\/2021]. 2) Author unknown, Wikipedia (date &hellip; <\/p>\n<p class=\"link-more\"><a href=\"http:\/\/biopedia.co.uk\/?p=529\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;33- Lethal Alleles&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/529"}],"collection":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=529"}],"version-history":[{"count":1,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/529\/revisions"}],"predecessor-version":[{"id":537,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/529\/revisions\/537"}],"wp:attachment":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=529"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}