{"id":588,"date":"2021-06-27T11:00:00","date_gmt":"2021-06-27T10:00:00","guid":{"rendered":"https:\/\/biopedia.co.uk\/?p=588"},"modified":"2021-07-22T14:34:46","modified_gmt":"2021-07-22T13:34:46","slug":"38-haemophilia","status":"publish","type":"post","link":"http:\/\/biopedia.co.uk\/?p=588","title":{"rendered":"38- Haemophilia"},"content":{"rendered":"<p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-588-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/anchor.fm\/s\/3d2240d8\/podcast\/play\/30814640\/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fproduction%2F2021-5-25%2F200324870-44100-2-4e46a68ff9c91.mp3?_=1\" \/><a href=\"https:\/\/anchor.fm\/s\/3d2240d8\/podcast\/play\/30814640\/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fproduction%2F2021-5-25%2F200324870-44100-2-4e46a68ff9c91.mp3\">https:\/\/anchor.fm\/s\/3d2240d8\/podcast\/play\/30814640\/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fproduction%2F2021-5-25%2F200324870-44100-2-4e46a68ff9c91.mp3<\/a><\/audio>Haemophilia is a genetic condition which is characterised by one of the blood clotting factors, usually encoded for on the X chromosome, not being encoded for properly for various reasons- whether it&#8217;s a mobile genetic element inserting itself into the gene or a simple mutation. On the show today, we describe the cause and symptoms of haemophilia, as well as using the case study of Queen Victoria to show that new mutations are a surprisingly common root cause&#8230;<br \/>\nSources for this episode:\u00a01-2) Wikipedia entries for Factor VIII and Queen Victoria (online) [Accessed 08\/04\/2021]. 3) Thain, M. and Hickman, M. (2014), Dictionary of Biology (Eleventh Edition). London: Penguin Books Ltd. 4) Author unknown, The Haemophilia Society (date unknown), Bleeding Disorders &gt; Haemophilia (online) [Accessed 08\/04\/2021]. 5) Francioli, L. C., et al. (2015), Genome-wide patterns and properties of de novo mutations in humans. Nature Genetics 47(7): 822- 826. 6) Mannucci, P. M. and Tuddenham, E. G. D. (2001), The Haemophilias- From Royal Genes to Gene Therapy. The New England Journal of Medicine 344(23): 1773- 1779.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haemophilia is a genetic condition which is characterised by one of the blood clotting factors, usually encoded for on the X chromosome, not being encoded for properly for various reasons- whether it&#8217;s a mobile genetic element inserting itself into the gene or a simple mutation. On the show today, we describe the cause and symptoms &hellip; <\/p>\n<p class=\"link-more\"><a href=\"http:\/\/biopedia.co.uk\/?p=588\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;38- Haemophilia&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/588"}],"collection":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=588"}],"version-history":[{"count":1,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/588\/revisions"}],"predecessor-version":[{"id":598,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/588\/revisions\/598"}],"wp:attachment":[{"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=588"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopedia.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}