As discussed in previous episodes, the actin cytoskeleton is vital to allow cells to move. But what about the specifics? In this episode, we’re going to be dissecting the lamellipodium- a meshwork actin structure that some cells use to move.
Sources for this episode: 1) Alberts, Johnson, Lewis, Raff, Roberts, and Walter (2008), Molecular Biology of the Cell, Fifth Edition. Abingdon: Garland Science, ‘Taylor and Francis Group LLC’ 2) ‘Mechanobiology Institute, Singapore’, 2013 (YouTube), Arp2/3 complex mediated actin nucleation (online) [Accessed 23/11/2020] 3) Berro, Michelot, Blanchoin, Kovar and Martiel (2007), Attachment Conditions Control Actin Filament Buckling and the Production of Forces. Biophysical Journal 92(7): 2546- 2558. 4) Kiuchi, Ohashi, Kurita and Mizuno (2007), Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers. The Journal of Cell Biology 177(3): 465- 476.